Emergence of Antimicrobial Resistance among Pseudomonas aeruginosa: Implications for Therapy

Joseph P. Lynch III; George G. Zhanel; Nina M. Clark

doi:10.1055/s-0037-1602583

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2017; 38(03): 326-345
DOI: 10.1055/s-0037-1602583

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Emergence of Antimicrobial Resistance among Pseudomonas aeruginosa: Implications for Therapy

Joseph P. Lynch III

¹Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California

,

George G. Zhanel

²Department of Medical Microbiology/Infectious Diseases, Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

,

Nina M. Clark

³Division of Infectious Diseases, Department of Medicine, Loyola University Medical Center, Maywood, Illinois

› Author Affiliations

Abstract

Pseudomonas aeruginosa (PA), a nonlactose fermenting gram-negative bacillus, is a common cause of nosocomial infections in critically ill or debilitated patients, particularly ventilator-associated pneumonia (VAP), and infections of bloodstream, urinary tract, intra-abdominal, wounds/skin/soft tissue. PA rarely affects healthy individuals, but may cause serious infections in patients with chronic structural lung disease, comorbidities, advanced age, impaired immune defenses, or with medical devices (e.g., urinary or intravascular catheters, foreign bodies). Treatment of pseudomonal infections is difficult, as PA is intrinsically resistant to multiple antimicrobials, and may acquire new resistance determinants even while on antimicrobial therapy. Mortality associated with pseudomonal VAP or bacteremias is high (> 35%) and optimal therapy is controversial. Over the past three decades, antimicrobial resistance among PA has escalated globally, via dissemination of several international multidrug-resistant “epidemic” clones. We review the emergence of antimicrobial resistance to this pathogen, and discuss approaches to therapy (both empirical and definitive).

Keywords

multidrug resistance - antimicrobial resistance - Pseudomonas aeruginosa - plasmids - clonal spread - carbapenemases - ventilator-associated pneumonia

Full Text

References

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